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Manchester Institute for Collaborative Research on Ageing

Upcoming Conference on Protein misfolding in ageing and neurodegeneration

8 March 2018

On 26 -28 March, Kings College London host a UK-Israel Synergy Symposium on Protein misfolding in ageing and neurodegeneration: from basic biology to drug development. Protein misfolding is a key early step in the pathology of several neurodegenerative disorders connected to ageing, such as Alzheimer’s and Parkinson’s diseases. It leads to the formation of neurotoxic protein aggregates called amyloids, which interfere with the communication between neurons and, eventually, brings to cell death.

This event aims to bring together top UK and Israeli scientists working in different fields of protein misfolding related to aging and frailty diseases to share new ideas and results.

Event organiser, Dr Elsa Zacco of King’s College London says: “With this symposium we aim at offering to our colleagues and graduate students in UK and Israel an important chance to establish new collaborations between the two countries, allowing vigorous debate and face-to-face conversations. We want to support the possibility for researchers of both countries to focus on specific, selected issues, offering concrete examples of research studies conducted by both parties and, most of all, becoming aware of the tangible progresses we can achieve joining facilities and expertise.

The event will allow open confrontation of research stimuli and will support active collaborations, creating the ground for skill and competence transfer and for student mobility. We hope to establish new educational methods to enhance uptake of knowledge and practical skills for our researchers, which will gain the greatest advantages from additional UK-Israel partnerships.”

The meeting will include the following topics of discussion:

  • The mechanisms of neurodegeneration in ageing, which will focus on the mechanisms that trigger protein misfolding during aging;
  • Molecular chaperons in ageing-related neurodegeneration, which will focus on protein folding-assisted processes, what can cause their failure and the consequent cellular stress responses;
  • Prion-like behaviour in ageing diseases, which will help a better understanding of how prions cause tissue damage leading to further aggregation and neurodegeneration;
  • The cross-talk between different ageing diseases, where the relationship between the mechanisms that triggers ageing diseases will be discusses;
  • Molecular mechanisms of unfolding and aggregation, which will bring the attention towards the intra- and inter-molecular interactions that lead to conformational rearrangements in proteins;
  • The role of post-translational modifications in aggregation, in which the role of phosphorylation, glycosylation, ubiquitination and other epigenetic events will be discussed.

By moving towards the identification of new therapeutic targets, the conference aims to contribute in the improvement of the health and well-being of both patients and caregivers, and to reduce economic burden from medical care and loss of productivity.

The meeting costs £200 for senior scientists and £150 for students.

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