Ageing, health and early life development
Insights from embryology and paediatrics on later life outcomes
Tuesday 23 June 2015
- Dr Adam Stevens, Senior Research Associate, Manchester Academic Health Sciences Centre, University of Manchester - 'Healthy ageing and growth in early life: the interaction between genes, the environment and development'
- Dr Philip Murray, NIHR Clinical Lecturer, Institute of Human Development, The University of Manchester Professor - 'Early Life Growth Patterns and Later Life Metabolic Consequences'
- Professor Daniel Brison, Honorary Professor. Institute of Human Development, The University of Manchester - 'Does spending the first 5 days of your life in a test tube affect your health? Lessons from In Vitro Fertilisation'
- Chair - Professor Peter Clayton, Professor, Institute of Human Development, The University of Manchester
Health in later life is strongly related to how we grow and develop in the womb and through childhood. Limiting the supply of nutrients to the foetus has been shown to lead to changes in how genes work. In particular, poor foetal growth is associated with heart disease, stroke, diabetes and high blood pressure later in life. Prevention of these chronic conditions could be improved if their relationships to early life events were better understood.
This seminar presented research that looks at how poor health in later life is associated with foetal and child growth highlighting the possibility for early intervention to prevent disease in old age. We shared research from the University of Manchester on how networks of genes change associated with age across the early embryo, infancy, childhood and adolescence. We showed how these changes relate to the different phases of growth through childhood and can be mapped to health in later life.